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Isofol Appoints The Sage Group to Identify Strategic Partnerships for its Novel Modufolin® Chemotherapy Asset

February 4, 2015

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Isofol (www.isofolmedical.com), a clinical stage pharmaceutical company based in Gothenburg, Sweden, announces that following an internal review, it has launched a global program to identify one or more strategic partners for commercialization of its Modufolin® chemotherapy asset. The Sage Group (based in Europe, USA and Asia) has been appointed by Isofol to assist the company in this endeavor. The overall objective is to identify a well-established pharma partner who will work with the company to exploit the value of Modufolin® in what is believed to be a multi billion dollar market.

 

Jan-Eric Osterlund, Executive Chairman of Isofol, said “We are delighted to be working with The Sage Group, who are providing us with access to a global network of potential partners for our exciting Modufolin® asset. We are conducting two Phase 1/2 clinical trials with Modufolin® in colorectal cancer and in osteosarcoma and intend to work with a strategic partner on these and future trials. We expect this will lead to market approval worldwide and a much improved response rate for conventional chemotherapy. Identifying the correct partner(s) will be key to successful commercialization of this asset leading to improved patient outcomes because of its novel mode of action.”

 

Isofol believes that around 70% of patients are unable to achieve successful metabolic activation of leucovorin and levoleucovorin (today’s standard folate treatment in cancer) and thus fail to fully benefit from their chemotherapy treatment. As Modufolin® is the key active metabolite of leucovorin and levoleucovorin, it does not need to be activated in the body. Modufolin® thereby has the potential to enable these patients to more fully benefit from their chemotherapy treatments in the future, including 5-­fluorouracil (5-FU), one of the most prescribed chemotherapies today. Isofol’s ongoing clinical trials are focusing on colorectal cancer and osteosarcoma, but the potential reaches beyond that to other solid tumor cancers like pancreatic and gastric cancers.

 

Isofol Medical AB has recently announced publication of a study comparing t